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Citrulline (L-Citrulline Base)

L-citrulline is a protein-free semi-essential amino acid. Citrulline is said to be non-protein, because unlike other classic amino acids, food does not tend to provide citrulline.

Only watermelon offers a little (about 1 g per kilo).

Consequently, all our citrulline has to be synthesised from the intestinal destruction of various other amino acids such as glutamine and arginine. On the other hand, in the kidneys, citrulline is largely converted into arginine.

Take 3 g (3 scoops) either 1 hour before training or divided into morning and evening meals.

  • BioKyowa® L-Citrulline: Expert Japanese manufacturing
  • Plant-based amino acid
  • Allergen-free

L-citrulline is a protein-free semi-essential amino acid. Citrulline is said to be non-protein, because unlike other classic amino acids, food does not tend to provide citrulline.

Only watermelon offers a little (about 1 g per kilo).

Consequently, all our citrulline has to be synthesised from the intestinal destruction of various other amino acids such as glutamine and arginine. On the other hand, in the kidneys, citrulline is largely converted into arginine.

3 g of Nutrimuscle L-citrulline base is considered an effective dosage. For example, men and women were given varying doses of L-citrulline for 7 days (1). Taking 1.5 g of Nutrimuscle L-citrulline base has the same effect as taking 3.2 g of Nutrimuscle L-arginine base on your blood arginine level. However, 3 g of Nutrimuscle L-citrulline base per day is required to achieve an increase in NO production.

If your main goal is congestion, use Nutrimuscle L-citrulline base, in conjunction with Nutrimuscle L-arginine base if possible.

Some people respond quickly to the vasodilator effects of citrulline

, but this is not the case for everyone. It takes 3 weeks of daily use of Nutrimuscle L-citrulline base to determine the individual effectiveness of this amino acid.

Side effects of citrulline

The studies report no side effects from moderate doses of citrulline. At high doses (more than 10 g), some digestive problems were reported.

Vegan capsule (pullulan)

Active Ingredients per serving (3 scoops)
L-citruline 3000 mg

Scientists long thought that citrulline was only a metabolic intermediary with little physiological influence (2). In other words, for glutamine to convert to arginine, you have to go through an intermediate step, which is the conversion of glutamine into citrulline; then, the kidneys convert citrulline into arginine. But citrulline by itself was not presumed to have any effect on our bodies.

It was in 1985 that researchers noted that blocking the intracellular production of citrulline inhibited the growth of animals (3). Reverse experiments were then carried out, in which rats were fed half their usual diet for 12 weeks, with or without citrulline supplementation (3). Muscular anabolism remained twice as high in rats receiving citrulline than in those subjected to calorie restriction alone. In the end, with citrulline, the muscles ended up 40% bigger (4). This anabolic effect of citrulline was then confirmed in humans (5-6-7-8-9).

Effects of citrulline

Taking citrulline increases arginine levels in the same way as taking L-arginine directly (12-13). Arginine supplements are partially deteriorated by digestion, which is not the case with citrulline (14). The latter benefits from almost perfect absorption.

With oral consumption, losses of citrulline via urine are minimal, which proves that the body's absorption and retention capacities are excellent, even at high doses (15). Therefore, 3 to 6 g of citrulline can double the level of arginine in the blood (16).

Citrulline and NO

Sporting activity induces a decrease in the level of citrulline in the blood (19-20). For example, after physical exertion, citrulline levels collapse by almost 50%, indicating that intense sporting activity increases our need for citrulline, but the body doesn't respond to this increased demand by increasing the rate of conversion of glutamine or arginine to citrulline (21).

One of the reasons why exercise consumes citrulline is because it forces the body to produce more NO, which in turn wastes citrulline (19). Whether we are athletic or feeling unwell, paradoxically, it is at times when we have an increased need for citrulline that our body starts to produce less of it (28). The only way to counteract this decline is to supplement with Nutrimuscle L-citrulline base.

Citrulline (L-Citrulline Base)

L-Citrulline is an amino acid that the body produces from Glutamine and Arginine.

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RRP: £14.95

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Does not replace a varied and balanced diet and a healthy lifestyle. Do not exceed the recommended daily portion. Store in a dry place away from heat and light and keep out of the reach of young children.

L-citrulline is a protein-free semi-essential amino acid. Citrulline is said to be non-protein, because unlike other classic amino acids, food does not tend to provide citrulline.

Only watermelon offers a little (about 1 g per kilo).

Consequently, all our citrulline has to be synthesised from the intestinal destruction of various other amino acids such as glutamine and arginine. On the other hand, in the kidneys, citrulline is largely converted into arginine.

Take 3 g (3 scoops) either 1 hour before training or divided into morning and evening meals.

  • BioKyowa® L-Citrulline: Expert Japanese manufacturing
  • Plant-based amino acid
  • Allergen-free

L-citrulline is a protein-free semi-essential amino acid. Citrulline is said to be non-protein, because unlike other classic amino acids, food does not tend to provide citrulline.

Only watermelon offers a little (about 1 g per kilo).

Consequently, all our citrulline has to be synthesised from the intestinal destruction of various other amino acids such as glutamine and arginine. On the other hand, in the kidneys, citrulline is largely converted into arginine.

3 g of Nutrimuscle L-citrulline base is considered an effective dosage. For example, men and women were given varying doses of L-citrulline for 7 days (1). Taking 1.5 g of Nutrimuscle L-citrulline base has the same effect as taking 3.2 g of Nutrimuscle L-arginine base on your blood arginine level. However, 3 g of Nutrimuscle L-citrulline base per day is required to achieve an increase in NO production.

If your main goal is congestion, use Nutrimuscle L-citrulline base, in conjunction with Nutrimuscle L-arginine base if possible.

Some people respond quickly to the vasodilator effects of citrulline

, but this is not the case for everyone. It takes 3 weeks of daily use of Nutrimuscle L-citrulline base to determine the individual effectiveness of this amino acid.

Side effects of citrulline

The studies report no side effects from moderate doses of citrulline. At high doses (more than 10 g), some digestive problems were reported.

Vegan capsule (pullulan)

Active Ingredients per serving (3 scoops)
L-citruline 3000 mg

Scientists long thought that citrulline was only a metabolic intermediary with little physiological influence (2). In other words, for glutamine to convert to arginine, you have to go through an intermediate step, which is the conversion of glutamine into citrulline; then, the kidneys convert citrulline into arginine. But citrulline by itself was not presumed to have any effect on our bodies.

It was in 1985 that researchers noted that blocking the intracellular production of citrulline inhibited the growth of animals (3). Reverse experiments were then carried out, in which rats were fed half their usual diet for 12 weeks, with or without citrulline supplementation (3). Muscular anabolism remained twice as high in rats receiving citrulline than in those subjected to calorie restriction alone. In the end, with citrulline, the muscles ended up 40% bigger (4). This anabolic effect of citrulline was then confirmed in humans (5-6-7-8-9).

Effects of citrulline

Taking citrulline increases arginine levels in the same way as taking L-arginine directly (12-13). Arginine supplements are partially deteriorated by digestion, which is not the case with citrulline (14). The latter benefits from almost perfect absorption.

With oral consumption, losses of citrulline via urine are minimal, which proves that the body's absorption and retention capacities are excellent, even at high doses (15). Therefore, 3 to 6 g of citrulline can double the level of arginine in the blood (16).

Citrulline and NO

Sporting activity induces a decrease in the level of citrulline in the blood (19-20). For example, after physical exertion, citrulline levels collapse by almost 50%, indicating that intense sporting activity increases our need for citrulline, but the body doesn't respond to this increased demand by increasing the rate of conversion of glutamine or arginine to citrulline (21).

One of the reasons why exercise consumes citrulline is because it forces the body to produce more NO, which in turn wastes citrulline (19). Whether we are athletic or feeling unwell, paradoxically, it is at times when we have an increased need for citrulline that our body starts to produce less of it (28). The only way to counteract this decline is to supplement with Nutrimuscle L-citrulline base.

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