Chondroitin sulphate is a glycosaminoglycan: an important component of joint cartilage, tendons, and skin. Because of this role, Chondroitin is considered to be one of the best supplements for protecting the joints.
Muscle growth and tissue regeneration
By promoting the production of hyaluronic acid, chondroitin sulfate not only protects the joints, but also promotes muscle growth.
Joint hydration and lubrication (9)
Chondroitin sulphate ensures joint flexibility and shock absorption.
Tendon flexibility and strength
Chondroitin sulfate helps to repair tendons by stimulating the local production of collagen, which ensures flexibility and resistance.
For further details on the benefits of Nutrimuscle Chondroitin Sulfate, visit the Find out more section.
Nutritional composition per 100 g:
- Protein 12.8 g
- Fat 1.9 g
- Carbohydrates 74.2 g
- Calories 365 kcal
- BCAA 0 g
Powdered Chondroitin Sulfate:
- Chondroitin sulfate.
Chondroitin Sulfate Capsules:
- Chondroitin sulfate;
- Beef gelatin capsule.
Nutrimuscle Chondroitin Sulfate is pharmaceutical grade. It combines chondroitins 4 and 6.
Nutrimuscle Chondroitin Sulfate is for:
- Athletes looking to improve their muscle growth
- Inactive people who suffer with their joints, especially if they have osteoarthritis.
Take 800 mg or 2 capsules per day.
Take the recommended daily dose with meals 12 hours apart (morning and evening meals) for optimal effectiveness over 24 hours.
Several studies have shown that a daily intake of 800 mg of chondroitin sulphate among sedentary patients with osteoarthritis produces the same effects as the use of 1200 mg (1).
The maximum concentration of chondroitin in the blood is reached about 4 hours after consumption. Eight hours later, the chondroitin sulfate has completely disappeared from the blood (2).
These average durations of action suggest that it is ideal to split your doses in half, taking half in the morning and half in the evening. A single dose (morning or evening) covers most of the day, which simplifies your consumption but is not quite optimal.
Synergies between supplements
There are 2 kinds of possible synergy with Chondroitin:
For an effect on joints and cartilage, combining with Peptan collagen peptide type llm and N-acetyl-Glucosamine
For skin hydration and an anti-wrinkle effect, combine with Peptan collagen peptide type I.
Adverse reactions between supplements
No known negative interactions with other supplements.
- (1) Volpi N. Analytical aspects of pharmaceutical grade chondroitin sulphates. J Pharm Sci. 2007 Dec;96(12):3168-80.
- (2) Volpi N. Quality of different chondroitin sulfate preparations in relation to their therapeutic activity. J Pharm Pharmacol. 2009 Oct;61(10):1271-80.
Find out more
It's rare for consumers to have access to the names of the suppliers of the raw materials that go into the supplements they consume. However, this is essential to ensure product traceability.
At Nutrimuscle, we only use the very best ingredients, the quality of which is guaranteed by global leaders: the French group Solabia, which is HACCP and ISO9001 certified, produces Nutrimuscle's Chondroitin sulphate.
What matters most to us is the quality of the raw materials, your health, and the results you achieve using our nutritional supplements. What’s more, Nutrimuscle Chondroitin sulphate boasts perfect traceability both in terms of the origin of the raw material and the fact that it comes from animals certified free from bovine spongiform encephalitis (BSE).
The extraction and purification of Nutrimuscle Chondroitin Sulfate does not involve any preservatives or surfactants. Nutrimuscle Chondroitin sulfate has a guaranteed minimum purity of 90%. This detail is important because research has clearly established that the less pure chondroitin is, the more ineffective, or even unhealthy, the product is for the joints (1).
Its heavy metal, microorganism, germ, and bacteria content is continuously analysed in order to comply with very strict standards.
The prices of chondroitin supplements vary greatly from brand to brand. Chromatographic analyses show that cheap chondroitin from China are of poor quality (2 - 3).
This quality issue, both in terms of the differences between the dosages given on the box and the actual dosages, as well as the presence of toxic residues, has prompted European health authorities to ban the sale of Chinese chondroitin.
Unfortunately, there are many loopholes for retailers to exploit. As a result, poor quality chondroitin is still available on the market.
As we have just seen, within the joint, chondroitin sulphate alleviates painful inflammatory phenomena, prevents joint degradation and has the property of reconstructing cartilage (12). However, people suffering from joint problems have cartilage that is gradually depleted of chondroitin. It seems logical to increase the concentration of chondroitin through an external contribution.
Because of the diversity of its modes of action, chondroitin sulphate will produce effects that materialise differently over time. If its natural anti-inflammatory action appears quickly, its protective and especially repairing effects will take longer to materialise.
Effects after 6 months
A recent medical study analysed the effectiveness of a daily treatment with 400 mg of chondroitin sulphate twice a day (total intake 800 mg), for 6 months, in patients suffering from knee pain (13). With placebo, the total volume of knee cartilage decreased by 4.67% in 6 months compared to 2.87% with chondroitin.
Effects after one year
For 12 months, patients with knee pain received either a placebo or chondroitin (14). With chondroitin, the total volume of knee cartilage increased by 180 mm3 while in the placebo group it was reduced by 46 mm3. The result was of course a reduction in the pain threshold in the chondroitin sulphate group compared to the placebo group.
Effects after two years
For two years, patients with knee pain used either 800 mg of chondroitin or a placebo daily (15). Radiographic measurements of cartilage revealed :
A 7% decrease in mean thickness with placebo;
A 5.6% decrease in total cartilage surface area with placebo;
These degenerations are completely inhibited under chondroitin.
These degenerations are completely inhibited by chondroitin. A long-term regenerative action is therefore produced by chondroitin. Numerous other studies confirm the effectiveness of chondroitin sulphate (16 to 30 - 31 - 45 - 46 - 47).
Long-term side effects?
The drugs used to treat joint pain (synthetic anti-inflammatory drugs) have many harmful side effects. What about natural "joint" supplements like Nutrimuscle N-acetylglucosamine and Nutrimuscle Chondroitin Sulphate?
Fortunately, their safety is considered excellent both in the short and long term (33). Chondroitin treatment for 6 consecutive months does not induce any side effects in users (32). A long-term medical analysis measured the impact on health of glucosamine and chondroitin (used alone or in combination) over 6 to 8 years. More than 77,000 patients aged between 50 and 76 years at the start of the study were surveyed. Those who used glucosamine and chondroitin regularly were significantly less likely to die than others (34).
Glucosamine reduced the risk of death by 18%, while chondroitin reduced it by 14%. Glucosamine is particularly effective in reducing the risk of death from cancer and respiratory diseases (34-35). In addition to improved mobility, which is a factor in longevity because it allows people to remain more active and therefore healthier, glucosamine and chondroitin have anti-inflammatory effects that could be beneficial to general health in addition to that of the joints.
By increasing longevity in the long term, glucosamine and chondroitin have proven to be safe for health, which answers questions about their long-term side effects.
In addition to the fact that chondroitin sulphate serves as a raw material for cartilage, this natural food supplement also performs other vital functions in cartilage, especially for athletes by :
- Combating the breakdown of cartilage cells (3-4);
- exerting a natural anti-inflammatory action (3-5-6);
- Combating the free radicals that attack our cells (7);
- Promoting muscle growth and tissue regeneration (8-4).
By promoting the production of hyaluronic acid, chondroitin not only protects the joints, but will also promote muscle growth. Indeed, in addition to its beneficial effects on joint health, hyaluronic acid is also involved in muscle growth (11).
Hyaluronic acid acts in two different ways to make muscles grow and strengthen them:
- A direct action on the muscle cells on which hyaluronic acid accelerates the anabolism of contractile proteins (actin and myosin) (11).
- An indirect action on the muscle architecture. In our muscles, the contractile proteins are held in place by a whole tangle of collagen proteins. It is by anchoring themselves powerfully to this solid structure that our muscles can contract.
However, when we train, we destroy not only the contractile proteins, but also the entire collagen mesh that holds them together and the tendons. In order to recover, this entire structure must be rebuilt: this reconstruction process is one of the tasks of hyaluronic acid and chondroitin.
Chondroitin will therefore participate in muscle hypertrophy and strength gain by :
- Increasing mechanical resistance to friction;
- Moisturising and lubricating the joint (9), ensuring its flexibility and absorbing shocks.
In addition to direct mechanisms of action, chondroitin sulphate also produces indirect benefits on the joints. Scientific studies have shown that chondroitin increases the activity of enzymes responsible for the production of hyaluronic acid (a lubricant and anabolic food for the joints) (10).
The increase in hyaluronic acid production by chondroitin is a good thing, because by overloading his muscles, the athlete accelerates the destruction of his articular hyaluronic acid. Athletes therefore have a greater need for hyaluronic acid; a need that chondroitin sulphate will help to meet, bringing flexibility and resistance to the tendons.
Chondroitin does not only act on the joints or muscles. It also helps to repair tendons by stimulating the local production of collagen. It is collagen that gives tendons flexibility and strength. The need to repair collagen structures is increased by sporting activity, as these proteins are damaged and destroyed by the repetition of intense muscle contractions. Chondroitin therefore contributes to the recovery of joints, muscles and tendons.
If you were to choose only one joint supplement for budget reasons, we recommend Nutrimuscle N-acetylglucosamine over all other supplements. However, in this case, your joint protection would not be total, as we shall see.
It has long been questioned whether glucosamine and chondroitin are not duplicating each other by acting through similar mechanisms of action. It would therefore be pointless to take them both.
However, recent research carried out directly on the genes shows that glucosamine and chondroitin act in different and complementary ways on the joints. There is therefore a synergy between these two joint protectors, which is why it is better to use them together rather than separately (39-40-41).
Pharmacoproteomics is a science that analyses the influence of a molecule (food supplement, drug, etc.) on our genes in order to determine its mode of action and predict its possible side effects. To do this, people used either glucosamine or chondroitin or both. The activity of their genes in the joint cartilage was measured before and after taking the drug. The activity of more than thirty genes is modified by either glucosamine or chondroitin (42). The activity of some genes, such as those responsible for cartilage repair, increased, while others, such as those that activate cartilage destruction, decreased.
Thus, we can say that :
- N-acetylglucosamine essentially promotes cartilage repair while slightly decreasing catabolism;
- Chondroitin mainly reduces the catabolism of cartilage while slightly stimulating its regeneration.
There is therefore a complementary action between the two supplements: one is anabolic for N-acetylglucosamine, the other is anti-catabolic for chondroitin. But the study goes further by showing that certain genes were activated only in the presence of glucosamine + chondroitin, but not with one of the two supplements used in isolation, which proves the synergy between these two molecules; each complementing the other (42).
This was demonstrated in the following study, where knee patients were given either :
- 1.2 g of chondroitin sulphate,
- 1.5 g glucosamine,
- 1.2 g chondroitin + 1.5 g glucosamine (43).
Amongst those in greatest pain, pain was reduced in :
- 48% of patients on placebo,
- 58% of patients on chondroitin,
- 66% of patients on glucosamine,
- 75% of patients on chondroitin + glucosamine.
The results of other medical studies also show that chondroitin and glucosamine are complementary to omega 3 (44). Glucosamine acts mainly on the repair genes, whereas chondroitin is more responsible for providing energy to these repair genes and reduces those that accelerate the destruction of cartilage (48).
- (1) Tat SK. Variable effects of 3 different chondroitin sulfate compounds on human osteoarthritic cartilage/chondrocytes: relevance of purity and production process. J Rheumatol. 2010 Mar;37(3):656-64.
- (2) Volpi N. Analytical aspects of pharmaceutical grade chondroitin sulfates. J Pharm Sci. 2007 Dec;96(12):3168-80.
- (3) Volpi N. Quality of different chondroitin sulfate preparations in relation to their therapeutic activity. J Pharm Pharmacol. 2009 Oct;61(10):1271-80.
- (12) Wang L. Influence of polysulphated polysaccharides and hydrocortisone on the extracellular matrix metabolism of human articular chondrocytes in vitro. Clin Exp Rheumatol. 2002 Sep-Oct;20(5):669-76.
- (13) Wildi LM. Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as early as 6 months after initiation of therapy: a randomised, double-blind, placebo-controlled pilot study using MRI. Ann Rheum Dis. 2011 June 1; 70(6): 982–989.
- (14) Railhac JJ. Effect of 12 months treatment with chondroitin sulfate on cartilage volume in knee osteoarthritis patients: a randomized, double-blind, placebo-controlled pilot study using MRI.Clin Rheumatol. 2012 Jun 23. [Epub ahead of print]
- (15) Mathieu P. [Radiological progression of internal femoro-tibial osteoarthritis in gonarthrosis. Chondro-protective effect of chondroitin sulfates ACS4-ACS6]. Presse Med. 2002 Sep 14;31(29):1386-90.
- (16) Bruyere O. Glucosamine and chondroitin sulfate as therapeutic agents for knee and hip osteoarthritis. Drugs Aging. 2007;24(7):573-80.
- (17) Reginster JY. Symptom and structure modifying properties of chondroitin sulfate in osteoarthritis. Mini Rev Med Chem. 2007 Oct;7(10):1051-61.
- (18) Monfort J. Chondroitin sulphate for symptomatic osteoarthritis: critical appraisal of meta-analyses. Curr Med Res Opin. 2008 May;24(5):1303-8. Epub 2008 Apr 15.
- (19) Uebelhart D. Clinical review of chondroitin sulfate in osteoarthritis. Osteoarthritis Cartilage. 2008;16 Suppl 3:S19-21.
- (20) Gabay C. Symptomatic effects of chondroitin 4 and chondroitin 6 sulfate on hand osteoarthritis: a randomized, double-blind, placebo-controlled clinical trial at a single center. Arthritis Rheum. 2011 Nov;63(11):3383-91.
- (21) Möller I. Effectiveness of chondroitin sulphate in patients with concomitant knee osteoarthritis and psoriasis: a randomized, double-blind, placebo-controlled study. Osteoarthritis Cartilage. 2010 Jun;18 Suppl 1:S32-40.
- (22) Henrotin Y. Chondroitin sulfate in the treatment of osteoarthritis: from in vitro studies to clinical recommendations. Ther Adv Musculoskelet Dis. 2010 Dec;2(6):335-48.
- (23) Hochberg MC. Structure-modifying effects of chondroitin sulfate in knee osteoarthritis: an updated meta-analysis of randomized placebo-controlled trials of 2-year duration. Osteoarthritis Cartilage. 2010 Jun;18 Suppl 1:S28-31.
- (24) Pavelka K. Efficacy and safety of piascledine 300 versus chondroitin sulfate in a 6 months treatment plus 2 months observation in patients with osteoarthritis of the knee. Clin Rheumatol. 2010 Jun;29(6):659-70.
- (25) Rainsford KD. Importance of pharmaceutical composition and evidence from clinical trials and pharmacological studies in determining effectiveness of chondroitin sulphate and other glycosaminoglycans: a critique. J Pharm Pharmacol. 2009 Oct;61(10):1263-70.
- (26) Lee YH. Effect of glucosamine or chondroitin sulfate on the osteoarthritis progression: a meta-analysis. Rheumatol Int. 2010 Jan;30(3):357-63.
- (27) Reginster JY. In people with hand osteoarthritis, chondroitin sulphate therapy for 6 months improves pain and function compared with placebo. Evid Based Med. 2012 Apr 5. [Epub ahead of print]
- (28) Yue J. Chondroitin sulfate and/or glucosamine hydrochloride for Kashin-Beck disease: a cluster-randomized, placebo-controlled study. Osteoarthritis Cartilage. 2012 Jul;20(7):622-9.
- (29) Wildi LM. Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as early as 6 months after initiation of therapy: a randomised, double-blind, placebo-controlled pilot study using MRI. Ann Rheum Dis. 2011 Jun;70(6):982-9.
- (30) Henrotin Y. Intra-articular use of a medical device composed of hyaluronic acid and chondroitin sulfate (Structovial CS): effects on clinical, ultrasonographic and biological parameters. BMC Res Notes. 2012 Aug 4;5(1):407.
- (31) Schneider H. Symptom-modifying effect of chondroitin sulfate in knee osteoarthritis: a meta-analysis of randomized placebo-controlled trials performed with structum(®). Open Rheumatol J. 2012;6:183-9. Epub 2012 Jul 25.
- (32) Shmidt EI. [Long-term efficacy and safety of chondroitin sulphate (structum, France) in patients with coxarthrosis]. Ter Arkh. 2007;79(1):65-7.
- (33) Vangsness CT Jr. A review of evidence-based medicine for glucosamine and chondroitin sulfate use in knee osteoarthritis. Arthroscopy. 2009 Jan;25(1):86-94.
- (34) Bell GA. Use of glucosamine and chondroitin in relation to mortality. Eur J Epidemiol. 2012 Jul 25. [Epub ahead of print]
- (35) Brasky TM. Use of glucosamine and chondroitin and lung cancer risk in the VITamins And Lifestyle (VITAL) cohort. Cancer Causes Control. 2011 Sep;22(9):1333-42. Epub 2011 Jun 25.
- (39) Zhang YX. Effects of chondroitin sulfate and glucosamine in adult patients with Kaschin-Beck disease. Clin Rheumatol. 2010 Apr;29(4):357-62.
- (40) Tat SK. Chondroitin and glucosamine sulfate in combination decrease the pro-resorptive properties of human osteoarthritis subchondral bone osteoblasts: a basic science study. Arthritis Res Ther. 2007;9(6):R117.
- (41) Lippiello L. Collagen Synthesis in tenocytes, ligament cells and chondrocytes exposed to a combination of Glucosamine HCl and chondroitin sulfate. Evid Based Complement Alternat Med. 2007 Jun;4(2):219-24.
- (42) Calamia V. Pharmacoproteomic study of the effects of chondroitin and glucosamine sulfate on human articular chondrocytes. Arthritis Research & Therapy 2010, 12:R138 ;
- (43) Clegg DO.Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med. 2006 Feb 23;354(8):795-808.
- (44) Jerosch J. Effects of Glucosamine and Chondroitin Sulfate on Cartilage Metabolism in OA: Outlook on Other Nutrient Partners Especially Omega-3 Fatty Acids. Int J Rheumatol. 2011; 2011: 969012.
- (45) Kubo M. Chondroitin sulfate for the treatment of hip and knee osteoarthritis: current status and future trends. Life Sci. 2009 Sep 23;85(13-14):477-83.
- (46) Hochberg MC. The rate of decline of joint space width in patients with osteoarthritis of the knee: a systematic review and meta-analysis of randomized placebo-controlled trials of chondroitin sulfate. Curr Med Res Opin. 2008 Nov;24(11):3029-35.
- (47) Rubio-Terrés C. [An economic evaluation of chondroitin sulfate and non-steroidal anti-inflammatory drugs for the treatment of osteoarthritis. Data from the VECTRA study]. Reumatol Clin. 2010 Jul-Aug;6(4):187-95.
- (48) Calamia V. Secretome analysis of chondroitin sulfate-treated chondrocytes reveals its anti-angiogenic, anti-inflammatory and anti-catabolic properties. Arthritis Research & Therapy 2012, 14:R202.
Certificates and studies
- Chondroitin and glucosamine to restore cartilage?
- Glucosamine and chondroitin against inflammation ?
- Glucosamine and chondroitin against osteoarthritis of the knee
- How does articular cartilage break down with age?
- How effective are glucosamine and chondroitin?
- How effective are joint supplements against pain?
- Chondroitin reduces joint pain
- How effective are glucosamine and chondroitin against cancer?
- Chondroitin reduces joint catabolism
- Is irradiated food good for you?
- chondroitin preserves cartilage and reduces pain
- glucosamine + chondroitin: effective against pain
- the use of food supplements is beneficial to health
- how glucosamine + chondroitin improve health
- the effectiveness of chondroitin is finally recognised
- effective glucosamine + chondroitin synergy
- glucosamine + chondroitin help repair ligaments
- glucosamine + chondroitin protect joints
- glucosamine, chondroitin and fibres protect our cells
- chondroitin + glucosamine more effective together
- glucosamine + chondroitin against cancer
- daily variations in the thickness of knee cartilage
- chondroitin reduces joint pain
- glucosamine, chondroitin, omega 3 are anti-inflammatory