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Arginine (L-Arginine Base)

£14.95
  • The purest form and bioavailable
  • Increases strength and endurance 
  • Improves muscle congestion
  • Fights cardiovascular disease
  • Boosts libido
Amino acid to boost workouts and increase strength. Purest form Find out more
  • Booster
  • +
  • Congestion
  • Endurance
  • Strength
  • Capsules
Amount
  • 120 capsules
  • 400 capsules
  • 800 capsules
  • 1600 capsules
Optimal consumption date: 03/2023
£14.95
Quantity
- 1 +
  • Product offered from £50 purchase
  • Free delivery

Description

Why choose Nutrimuscle L-arginine?

At Nutrimuscle, we use only the highest quality L-arginine from Japan's leading pharmaceutical biotechnology company, BioKyowa Inc.
HACCP- and ISO9001-certified BioKyowa has been specialised in the production of pure amino acids for over 30 years.
Nutrimuscle L-arginine base is:

  • Produced by a patented fermentation process from vegetable sugar
  • 99.5% pure, which is above the pharmaceutical standard of 98%
  • GMO-free
  • Allergen-free (gluten-free, soy-free, peanut-free, seafood-free, etc.)

What is arginine?

Arginine is a semi-essential amino acid for inactive people. For athletes, arginine must be considered an essential amino acid, as physical activity increases the need for it. The body produces a small amount of arginine daily from glutamate, proline, and glutamine. But these conversions are not very effective because they do not compensate for the excessive losses of Arginine caused by regular muscular exertion.

What are the benefits of arginine?

Muscle congestion

For athletes, arginine supplementation increases nitric oxide (NO) levels, Creatine synthesis, and the elimination of metabolic waste products that cause fatigue, promoting blood flow to the muscles.

Fights against erectile dysfunction and cardiovascular disease


Arginine promotes the synthesis of Nitrogen Monoxide, a gas that is produced less and less by the body as you age. Deficiency can lead to blood circulation and erection problems.


Health and longevity


NO is one of the elements necessary for the biogenesis and bioenergy of mitochondria and stem cells. This gas helps the heart to work more efficiently by expanding the blood vessels.
For further details on the benefits of Nutrimuscle L-Arginine Base, visit the Find out more section.

Nutritional composition of Arginine

Nutritional values per 100 g : 

  • protein : 100g
  • Carbohydrates : 0g
  • Fat: 0g
  • Calories : 510 kcal

Ingredients

  • L-Arginine Base
  • Beef gelatin capsule

Composition

Nutritional composition

100 g1 capsule6 capsules
Proteins100 g0,53 g
3,18 g
Carbohydrates0 g0 g
0 g
Fat0 g0 g
0 g
Calories510 kcal2,7 kcal
16,2 kcal
Energy
2132 kJ
11,3 kJ
67,8 kJ

Usage tips

Who is Nutrimuscle L-Arginine base for?

Nutrimuscle L-Arginine base is for:

  • Athletes, for its effect on the blood flow to the muscles
  • Inactive people, for its multiple benefits on overall health

Dosage

Take 6 capsules per day with mineral water at room temperature.

When should I take Nutrimuscle L-Arginine base?

The rise in NO hits its peak 2 hours after Arginine consumption. Take Nutrimuscle L-Arginine Base on an empty stomach for faster action. However, this can increase the risk of digestive problems.

If you consume high doses of caffeine, taking Nutrimuscle L-Arginine Base 1 hour beforehand minimises the risk of heart palpitations, because pure caffeine accelerates the heart rate while causing vasoconstriction, which in turn impedes blood circulation. The result is a cardiac aberration, which explains the onset of palpitations. The Nutrimuscle L-Arginine Base acts by preventing vasoconstriction.

How do I take Nutrimuscle L-Arginine?

  • Occasional use: only take Nutrimuscle L-Arginine Base occasionally on days when you are training your weak points.
  • Full treatment: Prolonged Nutrimuscle L-Arginine Base treatments will help you to stay in good physical condition for longer ahead of each training session.


When you feel that the congestion has subsided, take a two-to-four-week break before taking Nutrimuscle L-Arginine Base again. It's clear that the less often you consume Nutrimuscle's L-Arginine Base, the longer its benefits in terms of congestion will last before reaching a plateau. This is why we don't recommend it on rest days.
Studies recommend between 2g and 6g of Arginine per day. The maximum dose of L-Arginine is around 9g; above this level, the risk of digestive problems increases sharply.

Arginine and digestive problems.
Arginine can induce digestive problems: in spite of being an amino acid, Arginine is not acidic. On the contrary, it is very alkaline (very high pH of 10 to 12). In comparison, it is much more alkaline than bicarbonate (hence a rather similar smell).
The digestive system needs time to adapt to such an alkaline element. We advise starting slowly (1 capsule) and gradually increasing your dosage. It is not so much the Arginine itself that can cause digestive problems, but the very high pH.
We recommend taking it with plenty of water. Redness, especially of the face, indicates the vasodilator effect of Arginine.

People with asthma should use this amino acid with caution.
Aside from these temporary effects that sometimes occur if you start using Arginine in high doses, side effects of taking Arginine are rare (1).
We highlight the fact that Arginine is one of the supplements whose long-term effects have been the most extensively studied due to its beneficial properties on the cardiovascular system (2 - 3 - 4 - 5).

Mixing with other Nutrimuscle products

Synergies between supplements
There is a synergy between Nutrimuscle's L-Arginine base and Nutrimuscle's L-citrulline base that maximises the secretion of NO. Combined with Nutrimuscle BCAAs, Nutrimuscle L-Arginine base fights against fatigue and accelerates recovery between close together training sessions.
Unlike other amino acids, Nutrimuscle L-Arginine base can be mixed with bicarbonate.
As a booster, the best thing to do is combine the Natural Bio Booster and Nutrimuscle's L-Arginine base, because they are both vasodilators, which facilitates your heart's job. The heart does not have to pump as hard when the blood vessels are dilated as it does when they are contracted and therefore narrower.

Adverse reactions between supplements

No known negative interactions with other supplements.

Scientific references

  • (1) Yaspelkis BB. The effect of a carbohydrate--arginine supplement on postexercise carbohydrate metabolism. Int J Sport Nutr. 1999 Sep;9(3):241-50.
  • (2) Monti LD. Effect of a long-term oral l-arginine supplementation on glucose metabolism: a randomized, double-blind, placebo-controlled trial. Diabetes Obes Metab. 2012 Oct;14(10):893-900.
  • (3) Jabecka A. Oral L-arginine supplementation in patients with mild arterial hypertension and its effect on plasma level of asymmetric dimethylarginine, L-citruline, L-arginine and antioxidant status. Eur Rev Med Pharmacol Sci. 2012 Nov;16(12):1665-74. 
  • (4) Bogdanski P. Effect of 3-month L-arginine supplementation on insulin resistance and tumor necrosis factor activity in patients with visceral obesity. Eur Rev Med Pharmacol Sci. 2012 Jun;16(6):816-23. 
  • (5) Bogdanski P. Supplementation with L-arginine favorably influences plasminogen activator inhibitor type 1 concentration in obese patients. A randomized, double blind trial. J Endocrinol Invest. 2013 Apr;36(4):221-6.

Find out more

High-quality products

How much L-Arginine is in my arginine?
Arginine is generally sold in two forms: L-Arginine, which is the purest form, and arginine hydrochloride, which results from the combination of hydrochloric acid + L-Arginine. So, when you consume 1 g of arginine hydrochloride, there isn't really 1 g of L-arginine in it, because 20% of your supplement is hydrochloric acid. Pure L-Arginine, the one used in Nutrimuscle's L-Arginine base, is 100% arginine, which makes it possible to take higher doses to assist muscle anabolism. On the contrary, hydrochloric acid has no anabolic function and has no health benefits. Arginine hydrochloride is a waste of money when it comes to choosing your supplements.

No chemical or genetic modifications
Unlike a lot of the low-cost arginine that is made from human hair, Nutrimuscle's L-Arginine base does not contain any animal or human substances. Nutrimuscle L-Arginine base is produced using a patented fermentation process involving plant-based sugar. Using exclusive purification techniques, the purity of Nutrimuscle L-Arginine Base reaches 99.5%, which is above the required pharmaceutical standard of 98%. The remaining 0.5% represents other amino acids.
The purity of L-Arginine base is guaranteed
While many cheap versions of arginine are produced in China, this is not the case for Nutrimuscle's L-Arginine base. Our L-Arginine is manufactured in an ultra-modern HACCP- and ISO9001-certified pharmaceutical factory in the United States by the Japanese BioKyowa group:
Nutrimuscle L-Arginine base is not made from GMOs.
It is manufactured without the use of GMO substances.
Nutrimuscle L-Arginine base does not contain allergens such as gluten, soy, peanuts, or shellfish extracts.
Being able to access this information seems to us to be of paramount importance: that's why we proudly display a list of all our our suppliers.

How does arginine work in the body?

A 21% drop in arginine levels is observed among endurance athletes after an intense run (1). For power athletes, a 90-minute workout reduces concentrations of arginine by 15% (2). In the same subjects, five weeks of intense strength training incurred a 19% reduction in arginine levels (3).

One of the reasons that exercise uses arginine is because it forces the body to produce more NO (see below), which automatically wastes arginine and forces the body to draw on its already low reserves (4-5). On the other hand, physical activity increases the activity of the enzyme arginase, which has several anti-arginine and anti-NO effects (6).

Arginase is responsible for destroying arginine, which prevents the arginine that we absorb (in the form of food or supplements) from reaching the bloodstream. It also blocks the transformation of arginine into NO due to its vascular activity. In doing so, the production of nitric oxide is weakened due to a lack of raw material. The combination of these negative phenomena explains why over-training is associated with a drop in blood arginine levels. In turn, a depletion in NO production is noted in athletes during periods of intense training (7). 

This is why when you over-train, congestion becomes less and less effective.
Even in the case of an arginine deficiency due to too little consumption, the body is unable to accelerate its own synthesis speed to compensate for increasing needs. Whey provides little arginine. Casein is a little richer in arginine, but not much. Arginine is not very present in food either. Supplementation is therefore recommended for athletes (8).

Effects of arginine

The positive effect of arginine has long been attributed solely to its ability to increase the secretion of growth hormone (GH), a hormone that promotes muscle gain and fat loss (9).

Growth hormone secretion is regulated by two hormones: GH-RH (for GH-Releasing hormone), which stimulates the secretion of GH, and somatostatin, which inhibits the secretion of GH. Arginine lowers the level of somatostatin, thereby increasing the secretion of GH (10). Today, three other mechanisms are added to the increase in GH levels to explain the benefits of arginine supplementation for athletes:

  • Increasing nitric oxide (NO) levels 
  • Increased creatine synthesis
  • The elimination of metabolic wastes that are vehicles for fatigue

Increased nitric oxide synthesis

NO is the acronym used for nitric oxide. Although it isn't a hormone, it's a gas that behaves very similarly to one. NO is produced and destroyed locally in seconds by the cells that require it. The scientific name for this family of molecules is gasotransmitters.

NO promotes muscular anabolism via both its direct and indirect effects on muscle cells, by promoting the proliferation of satellite cells (stem cells of new muscle fibres; 11-12-13-14-15-16-17-18-19). As a direct precursor of nitric oxide, arginine is the main natural booster of NO secretion. Arginine supplementation helps optimise anabolism without the need for testosterone, which is difficult to increase. On the contrary, NO production is relatively easy to increase. It has long been demonstrated that oral consumption of L-arginine causes an increase in cellular NO production (20).

The best known effect of NO is that it relaxes the smooth muscles that surround the arteries and blood vessels. This relaxation facilitates circulation in the muscles, which facilitates oxygenation and congestion. It is via this same mechanism that NO promotes male as well as female erection (of the clitoris). Carnitine can be coupled with arginine to produce even more NO to better oxygenate and nourish the muscles (21). 

Increased creatine synthesis

As a precursor to creatine, arginine increases the capacity for natural creatine synthesis, which in turn increases strength, muscle mass, and recovery. In order to optimise muscle creatine increase, we advise teaming arginine with glycine, which is the second natural creatine precursor. With L-Arginine base + glycine, you can reap all the benefits of creatine without having to take creatine directly (22-23). On the other hand, because of this same precursor mechanism, athletes' arginine needs are all the more important as creatine is not used (24).

Recycling metabolic waste

Arginine also acts as an anti-fatigue agent by accelerating the evacuation of metabolic waste, such as ammonia, an excess of which is produced during exercise (8-25-26). Once in the bloodstream, ammonia can easily reach the brain, where it exacerbates the feeling of exhaustion. It is during the use of ATP as energy that the catabolism of this molecule leads to ammonia production. Instead, arginine recycles metabolic waste products to synthesise ATP instead of forming ammonia. Arginine halves the increase in ammonia during exercise. Thus, taking arginine results in an increase in endurance, as well as in strength endurance (27-28-29-30).

Benefits related to L-Arginine base Nutrimuscle in more detail

Fight against erectile dysfunction and cardiovascular disease

Although erectile dysfunction has very diverse origins, there is a strong correlation between cardiovascular disease and erectile dysfunction (31). This correlation is partly explained by an overproduction of asymmetric dimethylarginine (ADMA). ADMA is an amino acid that the body naturally produces in small quantities, but whose synthesis increases with age. The production of NO becomes less and less abundant, which poses problems of blood circulation and therefore of erection.

ADMA causes deleterious effects through a dual mechanism: blocking the transport of arginine to enzymes that convert it into NO and inhibiting the activity of these enzymes. A simple way to reduce the production of asymmetric arginine derivatives is precisely to take arginine (31-32). This inhibition explains, in part, why taking arginine increases the production of NO, facilitates blood circulation and aids erection (33-34). For information, it is by preventing the destruction of NO that Viagra produces the effects that made it so famous. In men with erection problems, taking 5 g of L-arginine daily for 6 weeks significantly improves sexual function in 31% of users (35). It was the people who secreted the least NO at the start of the study who obtained the best results by doubling their production. Scientific studies have also shown that inhibiting the secretion of NO decreases the time it takes to achieve ejaculation. An underproduction of NO could partially explain ejaculations too early. Conversely, NO boosters like L-arginine help delay ejaculation.

Health and longevity

Many pathologies can be explained in part by a drop in NO production. For example, obesity or diabetes cause dysfunctions in the production of NO which is weakened. On the other hand, these NO deficits aggravate these pathologies. Moreover, in animals, it is those who manage to maintain a high production of NO that live longer than their counterparts who do not (36).

Human genetic studies describe the same tendency in centenarians to produce more NO than people who were not fortunate enough to reach this old age (37). The key to antiaging lies in the proper functioning of the mitochondria, which supply our cells with energy. The older our body gets, the fewer our mitochondria and the less well they function. NO is one of the building blocks for the biogenesis and bioenergy of mitochondria and stem cells (38). In addition, a too low production of NO is not desirable for health since this gas facilitates the work of the heart by widening the blood vessels. This explains the beneficial properties of arginine in people with cardiovascular problems. Arginine, via NO, thus allows better control of blood pressure, another factor in longevity (39).

Arginine and glutamine are two very important amino acids for maintaining human immune activity, particularly in athletes (40-41-42). In the event of infection, the need for arginine increases. Arginine, with its ability to increase the secretion of nitric oxide (which many immune cells use to destroy pathogens), is an interesting supplement against infections.

Scientific references

  • (1) Medelli J. Variation in plasma amino acid concentrations during a cycling competition. J Sports Med Phys Fitness. 2003 Jun;43(2):236-42.
  • (2) Pitkänen H. Serum amino acid responses to three different exercise sessions in male power athletes. J Sports Med Phys Fitness. 2002 Dec;42(4):472-80.
  • (3) Pitkänen H. Effects of training on the exercise-induced changes in serum amino acids and hormones. J Strength Cond Res. 2002 Aug;16(3):390-8.
  • (4) Bohdanovs'ka NV.[Nitric oxide synthesis during different stages of competition period in well-trained athletes]. Fiziol Zh. 2011;57(4):82-9.(e) Álvares TS. L-arginine as a potential ergogenic aid in healthy subjects. Sports Med. 2011 Mar 1;41(3):233-48.
  • (5) Bohdanovs'ka NV. [Nitric oxide synthesis during long-term adaptation to intensive muscular work in female sportsmen]. Fiziol Zh. 2009;55(3):94-9.
  • (6) Sureda A. Blood cell NO synthesis in response to exercise. Nitric Oxide. 2006 Aug;15(1):5-12.
  • (7) Bohdanovs'ka NV. [Characteristics of arginine metabolism and nitric oxide synthesis in young people during adaptation to physical load in training and competition periods]. Fiziol Zh. 2011;57(1):45-54.
  • (8) Campbell BI. The ergogenic potential of arginine. J Int Soc Sports Nutr. 2004 Dec 31;1(2):35-8.
  • (9) Wideman L. Synergy of L-arginine and GHRP-2 stimulation of growth hormone in men and women: modulation by exercise. Am J Physiol Regul Integr Comp Physiol. 2000 Oct;279(4):R1467-77.
  • (10) Wideman L. Synergy of L-arginine and growth hormone (GH)-releasing peptide-2 on GH release: influence of gender. Am J Physiol Regul Integr Comp Physiol. 2000 Oct;279(4):R1455-66.
  • (11) Long JH. arginine supplementation induces myoblast fusion via augmentation of nitric oxide production. J Muscle Res Cell Motil. 2006;27(8):577-84.
  • (12) Sellman JE. In vivo inhibition of nitric oxide synthase impairs upregulation of contractile protein mRNA in overloaded plantaris muscle. J Appl Physiol (1985). 2006 Jan;100(1):258-65.
  • (13) Smith LW. Involvement of nitric oxide synthase in skeletal muscle adaptation to chronic overload. J Appl Physiol (1985). 2002 May;92(5):2005-11.
  • (14) Steensberg A. Nitric oxide production is a proximal signaling event controlling exercise-induced mRNA expression in human skeletal muscle. FASEB J. 2007 Sep;21(11):2683-94.
  • (15) Tatsumi R. Satellite cell activation in stretched skeletal muscle and the role of nitric oxide and hepatocyte growth factor. Am J Physiol Cell Physiol. 2006 Jun;290(6):C1487-94.
  • (16) Rovere-Querini P. Nitric oxide and muscle repair: multiple actions converging on therapeutic efficacy. Eur J Pharmacol. 2014 May 5;730:181-5.
  • (17) Buono R. Nitric oxide sustains long-term skeletal muscle regeneration by regulating fate of satellite cells via signaling pathways requiring Vangl2 and cyclic GMP. Stem Cells. 2012 Feb;30(2):197-209.
  • (18) Gordon SE. Basal, but not overload-induced, myonuclear addition is attenuated by NG-nitro-L-arginine methyl ester (L-NAME) administration. Can J Physiol Pharmacol. 2007 Jun;85(6):646-51.
  • (19) Long JH. arginine supplementation induces myoblast fusion via augmentation of nitric oxide production. J Muscle Res Cell Motil. 2006;27(8):577-84.
  • (20) Kharitonov SA. L-arginine increases exhaled nitric oxide in normal human subjects. Clin Sci (Lond). 1995 Feb;88(2):135-9.
  • (21) Atalay Guzel N. Effects of acute L-carnitine supplementation on nitric oxide production and oxidative stress after exhaustive exercise in young soccer players. J Sports Med Phys Fitness. 2015 Jan-Feb;55(1-2):9-15.
  • (22) Valayannopoulos V. Treatment by oral creatine, L-arginine and L-glycine in six severely affected patients with creatine transporter defect. J Inherit Metab Dis. 2012 Jan;35(1):151-7.
  • (23) Leuzzi V. arginine and glycine stimulate creatine synthesis in creatine transporter 1-deficient lymphoblasts. Anal Biochem. 2008 Apr 1;375(1):153-5.
  • (24) Brosnan JT. The metabolic burden of creatine synthesis. Amino Acids. 2011 May;40(5):1325-31.
  • (25) Gonçalves LC. A sportomics strategy to analyze the ability of arginine to modulate both ammonia and lymphocyte levels in blood after high-intensity exercise. J Int Soc Sports Nutr. 2012 Jun 26;9(1):30.
  • (26) Schaefer A. L-arginine reduces exercise-induced increase in plasma lactate and ammonia. Int J Sports Med. 2002 Aug;23(6):403-7.
  • (27) Camic CL. The effects of 4 weeks of an arginine-based supplement on the gas exchange threshold and peak oxygen uptake. Appl Physiol Nutr Metab. 2010 Jun;35(3):286-93.
  • (28) Camic CL. Effects of arginine-based supplements on the physical working capacity at the fatigue threshold. J Strength Cond Res. 2010 May;24(5):1306-12.
  • (29) Yavuz HU. Pre-exercise arginine supplementation increases time to exhaustion in elite male wrestlers. Biol Sport. 2014 Aug;31(3):187-91.
  • (30) Bailey SJ. Acute L-arginine supplementation reduces the O2 cost of moderate-intensity exercise and enhances high-intensity exercise tolerance. J Appl Physiol (1985). 2010 Nov;109(5):1394-403.
  • (31) Wierzbicki AS. Asymmetric dimethyl arginine levels correlate with cardiovascular risk factors in patients with erectile dysfunction. Atherosclerosis. 2006 Apr;185(2):421-5.
  • (32) Calabrò RS. L-arginine and vascular diseases: lights and pitfalls! Acta Biomed. 2014 Dec 17;85(3):222-8.
  • (33) Lerman A. Long-term L-arginine supplementation improves small-vessel coronary endothelial function in humans. Circulation. 1998 Jun 2;97(21):2123-8.
  • (34) Mathers MJ. [Metabolism of nitric oxide (NO) and arginine: significance for male health]. Aktuelle Urol. 2009 Aug;40(4):235-41.
  • (35) Chen, W. Effect of oral administration of high-dose nitric oxide donor l-arginine in men with organic erectile dysfunction: results of a double-blind, randomized, placebo-controlled study. BJU International 1999 83: 269–273.
  • (36) Valerio A. Nitric oxide, interorganelle communication, and energy flow: a novel route to slow aging. Front. Cell Dev. Biol. 2015 06 February |
  • (37) Puca A A. Endothelial nitric oxide synthase, vascular integrity and human exceptional longevity. Immun. Ageing 2012.9:26.
  • (38) El-Hattab AW. Citrulline and arginine utility in treating nitric oxide deficiency in mitochondrial disorders. Mol Genet Metab. 2012 Nov;107(3):247-52.
  • (39) Dong JY. Effect of oral L-arginine supplementation on blood pressure: a meta-analysis of randomized, double-blind, placebo-controlled trials. Am Heart J. 2011 Dec;162(6):959-65.
  • (40) Field CJ. Glutamine and arginine: immunonutrients for improved health. Med Sci Sports Exerc. 2000 Jul;32(7 Suppl):S377-88.
  • (41) Field CJ. Glutamine and arginine: immunonutrients for improved health. Med Sci Sports Exerc. 2000 Jul;32(7 Suppl):S377-88.
  • (42) Cruzat VF. Amino acid supplementation and impact on immune function in the context of exercise. J Int Soc Sports Nutr. 2014 Dec 14;11(1):61.
  • (43) Yang Y. l-Leucine and NO-mediated cardiovascular function. Amino Acids March 2015 47(3) : 435-447.
  • (44) Yang Y. L-Leucine Inhibits Nitric Oxide Synthesis in Endothelial Cells. The FASEB Journal. 2013;27:1127.3
  • (45) Mels CM. The link between vascular deterioration and branched chain amino acids in a population with high glycated haemoglobin: the SABPA study. Amino Acids. 2013 Dec;45(6):1405-13.
  • (46) Hsu MC. Effects of BCAA, arginine and carbohydrate combined drink on post-exercise biochemical response and psychological condition. Chin J Physiol. 2011 Apr 30;54(2):71-8.
  • (47) Ohtani M. Amino acid mixture improves training efficiency in athletes. J Nutr. 2006 Feb;136(2):538S-543S.
  • (48) Ohtani M. Amino acid supplementation affects hematological and biochemical parameters in elite rugby players. Biosci Biotechnol Biochem. 2001 Sep;65(9):1970-6.
  • (49) Matsumoto K. Branched-chain amino acids and arginine supplementation attenuates skeletal muscle proteolysis induced by moderate exercise in young individuals. Int J Sports Med. 2007 Jun;28(6):531-8.

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