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Glucosamine is the main molecule capable of ensuring the right joint recovery, as it accelerates the body's ability to make glycosaminoglycans and hyaluronic acid.
Glucosamine is a precursor of gags, the second component of cartilages, tendons and ligaments, after collagen. Our body naturally produces its glucosamine from sugar and an amino acid: glutamine.
Good to know
La glucosamine est un composant essentiel utilisé par le corps pour synthétiser le cartilage, le tissu qui recouvre les extrémités des os dans les articulations.
What the product does
What the product does
Acceleration of the joint recovery process
N-acetylglucosamine accelerates the anabolism of cartilages so joint recovery. Research shows that the N-acetylglucosamine increases the speed of cartilage regeneration by 40 %.
No known immediate synergy.
No negative interaction known with other supplements.
In test tube, glucosamine is above all capable of inhibiting the degradation of existing joint cartilages and acts as a natural anti-inflammatory. It promotes lubrication and articular "nutrition" by stimulating the production of hyaluronic acid. There are several forms of glucosamine: glucosamine sulfate, glucosamine chlorhydrate, N-acetylglucosamine. What is the best?
N-acetylglucosamine Nutrimuscle is addressed:
to athletes who wish to prevent injuries, especially for force sports practitioners such as athletic force or bodybuilding, because heavy loads and repetitions Movements damage their joints. High impact sports athletes such as mountain biking or running also request their joints and have a profit to supplement to n-acetylglucosamine nutrimuscle;
to sedentary people who suffer from joint pain and wish to improve the comfort of their joints.
If you should only choose one joint supplement for budget issues, we would recommend the N-acetylglucosamine Nutrimuscle on all other supplements. But, in this case, your joint protection would not be total as we will see.
we have long wondered if glucosamine and chondroitine did not double work by acting by mechanisms of action similar. It would therefore be useless to take them both.
but recent research carried out directly on the genes show that glucosamine and chondroitine act in a different and complementary way on the joints. It is therefore created a synergy between these two articular protectors; This explains why it is preferable to use them together rather than separately (39-40-41).
Pharmacoproteomic is a science that analyzes the influence of a molecule (food supplement, medication .. .) On our genes to determine its mode of action and to predict its possible side effects.
To do this, people used either glucosamine or chondroitine or both times. The activity of their genes in joint cartilages was measured before and after this socket. The activity of more than thirty genes is modified by either glucosamine or by chondroitin (42).
some see their activity grow, like those responsible for repairing cartilages, others decrease , like those activating the destruction of cartilages.
So we can say that:
the n-acetylglucosamine essentially promotes cartilage repair while slightly decreasing catabolism,
Chondroitin mainly mitigates the catabolism of cartilage while slightly stimulating their regeneration.
There is therefore a complementarity of action between the two supplements: one is anabolic for N-acetylglucosamine, the other is anti-catabolic for Chondroitin. But the study goes further by showing that certain genes have only been activated in the presence of glucosamine + chondroitin only, but not with only one of the two supplements, used in isolation, which proves the synergy between these two molecules ; each complementing the other (42). This is demonstrated by the following study. For 24 weeks, patients with the knee received either:
1.2 g of chondroitin sulfate;
1.5 g of glucosamine;
1.2 g of chondroitin + 1, 5 g glucosamine (43).
Among the people who suffered the most, the pain was reduced in:
48 % of patients on placebo;
58 % of patients under chondroitine; < BR> 66 % of patients under glucosamine;
75 % of patients under chondroitin + glucosamine.
The results of other medical studies also show a complementarity of chondroitin and glucosamine with omega 3 (44). Glucosamine acts mainly on restorative genes while chondroitin is more responsible for providing energy to these repairing genes, and decreases those which accelerate the destruction of cartilages (48).
In sportsmen
In the world of sport, glucosamine was first used on a large scale on racing horses. From there, its use has spread to man. Indeed, if glucosamine reduces joint degeneration associated with aging, why not use it to protect cartilages undermined by the considerable repetition of sporting gestures? In a study carried out for 28 days, high -level athletes suffering from the knees received daily either:
a placebo;
1.5 g of glucosamine.
The recovery of the knee amplitude was 40 % faster under glucosamine than in placebo.
recently, Yoshimura (5) studied with precision the impact of an intense sport on the Cartilages of seasoned football players training 2 hours, six times a week. Compared to sedentary men of the same age, footballers have:
a level of degradation of joint cells which is multiplied by 300 %;
a speed of joint regeneration which increases only 43 % ;
A catabolism/anabolism ratio which is twice as high as normal.
Ideally, this ratio should be zero, testifying to an articulation that regenerates perfectly. Among the sedentary, it is 0.067, which corresponds to a very slow tendency to degeneration. In footballers, it is 0.135, which brings it to the same level as that of patients of 75 years suffering from osteoarthritis.
The turnover of joint cells is therefore greatly accelerated in the sportsman and a deficit reconstruction appears clearly. In the long run, it is normal for pain to appear.
Once these bases have been placed, Yoshimura had glucosamine take these footballers for 3 months:
A first group received 1, 5 g of glucosamine in the evening;
A second group received 1.5 g of glucosamine in the morning + 1.5 g in the evening.
After 3 months of daily grips, the catabolism/anabolism ratio decreases d 'About 15 % with the 1.5 g glucosamine and 25 % with the 3 g of glucosamine. These improvements are explained by reducing the magnitude of joint catabolism, and not by accelerating their regeneration. As we could expect, when the glucosamine is stopped, the level of degradation of the cartilage dates back to their levels before supplementation.
in this study, note that the effectiveness of glucosamine rises slowly in power over the weeks. Over the 3 months of the study, the benefits of supplementation do not seem to stagnate over time. This fact pleads in favor of long -term use rather than in the form of brief cures.
in sedentary
a sedentary person is already struggling to cover their glucosamine needs, which explains that 'Ultimately, the joints deteriorate slowly: it is osteoarthritis that develops, makes you suffer and limits mobility.
The regular grucosamine hold delays the progression of osteoarthritis (2). It also reduces the pain associated with it, while facilitating joint mobility (2). And, unlike painkillers, glucosamine causes no more side effects than a placebo.
in a three -year study in two hundred patients with knee osteoarthritis, the effectiveness of 1500 mg of glucosamine was compared to a placebo (3). Thanks to glucosamine, the level of pain has decreased and mobility has been improved by 24 %, while on placebo, a deterioration of 9 % was observed. Parameters such as the size of the interarticular space have also been measured. The more thin it, the more the joint and the cartilage are degenerate.
The bone ends up rubbing against the joint. With the placebo, this space was reduced on average by 0.31 mm in three years, while it was stable in the Glucosamine group. These differences demonstrate that glucosamine produces background action on cartilage and is not content to reduce pain.
long-term side effects
Medicines used against joint pain (anti-inflammatory drug of synthesis) induce many side effects harmful to health. What about natural "joint" supplements such as N-acetylglucosamine Nutrimuscle and chondroitin sulfate Nutrimuscle?
Fortunately, their safety is considered to be excellent, that it is short as in the long term (33). Chondroitin treatment of 6 consecutive months does not induce any side effects in users (32). A long -term medical analysis has measured the impact on the health of glucosamine and chondroitin (used alone or in combination) for 6 to 8 years. More than 77,000 patients aged 50 to 76 at the start of the study were questioned.
those who made regular use of glucosamine and chondroitine were much less likely to die than the others (34 ).
Glucosamine reduces the risk of mortality by 18 % while chondroitin decreases them by 14 %. Glucosamine is particularly effective in reducing the risk of death of cancer and respiratory diseases (34-35).
in addition to better mobility, factor of longevity, because allowing to stay more active and therefore in better Health, glucosamine and chondroitin have anti-inflammatory effects that could be beneficial to health in general in addition to that of joints. By increasing long -term longevity, glucosamine and chondroitine demonstrate their health safety, which answers questions regarding their long -term side effects. "
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